Article 10418

Title of the article



Kashutin Sergey Leonidovich, Doctor of medical sciences, professor, head of the sub-department of skin and venereal diseases, Northern State Medical University (51 Troitsky avenue, Arkhangelsk, Russia), E-mail:
Sherstennikova Aleksandra Konstantinovna, Candidate of medical sciences, associate professor, sub-department of normal physiology, Northern State Medical University, (51 Troitsky avenue, Arkhangelsk, Russia), E-mail:
Kalmin Oleg Vital'evich, Doctor of medical sciences, professor, head of the sub-department of human anatomy, Penza State University (40 Krasnaya street, Penza, Russia), E-mail:
Shutskiy Nikita Alekseevich, laboratory assistant researcher, Northern State Medical University (51 Troitsky avenue, Arkhangelsk, Russia), E-mail:
Shagrov Leonid Leonidovich, Junior researcher, Northern State Medical University (51 Troitsky avenue, Arkhangelsk, Russia), E-mail: 

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Background. Immunopathogenesis of psoriasis is due to the development of hyperproliferative processes in the epidermis occurring with impaired differentiation of keratinocytes. On the surface of keratinocytes there are special adhesive molecules, which, if necessary, attract neutrophilic leukocytes into the epidermis. Pathomorphological disorders in psoriasis are so diverse that there is an interest to identify its relationship with different types of physique.The purpose of the work was to compare the content of neutrophils carrying adhesion molecules in patients with psoriasis, taking into account anthropometry and somatometry data.
Materials and methods. The clinical and immunological examination of 82 patients aged 20 to 60 years, suffering from vulgar and exudative psoriasis in progressive and stationary stages. The study of the structure of somatotypes of psoriasis patients was carried out in accordance with the method proposed by L. Carter. Neutrophil content and cytoscopic examination were determined on a blood smear fixed with a mixture of Nikiforov and stained according to Romanovsky-Gimza.The concentration of neutrophils containing l-selectin molecules (CD62L), ICAM-1 (CD54), LFA-1 (CD11a), LFA-3 (CD58), PECAM-1 (CD31) was determined by Beckman Coulter flow cytometer FC-500).
Results. The lowest concentrations of neutrophils carrying adhesion molecules, in particular, L-selectin, ELAM-1 and LFA-3 were recorded in patients with psoriasis related to endomorphs, the highest values were observed in ectomorphs. In the structure segmentarray endomorphs there was a statistically significant low content of one-, three - and five-segmented forms of neutrophils. Significantly high concentrations of one - and five - segment forms were observed in ectomorphs.
Conclusion. Among patients with psoriasis, the most common person with endomorphic body type. The use of the method of somatotyping makes it possible to identify the individual characteristics of the course of this pathological process. 

Key words

psoriasis, adhesion molecules, neutrophils, somatotype 

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1. Tsvetkova G. M., Mordovtseva V. V., Vavilov A. M., Mordovtsev V. N. Patomorfologiya bolezney kozhi: rukovodstvo dlya vrachey [Pathomorphology of skin diseases: handbokk for doctors]. Moscow: Meditsina, 2003, 496 p.
2. Ghoreschi K., Rocken M. J. Dtsch. Dermatol. Ges. 2003, vol. 1 (7), pp. 524–32.
3. Smith C. J. J. AllergyClin. Immunol. 2008, vol. 3 (2), pp. 375–379.
4. Clark E. A., Brugge J. S. Science. 1995, vol. 268, pp. 233–239.
5. Muller W. A. Circ. Res. 2009, vol. 105 (3), pp. 223–230.
6. Dolgushin I. I., Bukharin O. V. Neytrofily i gomeostaz [Neutrophils and homeostasis]. Ekaterinburg, 2001, 280 p.
7. Pinegin B. V. Immunologiya [Immunology]. 2007, no. 28 (6), pp. 374–384.
8. Freydlin I. S., Totolyan A. A. Kletki immunnoy sistemy [Immune system cells]. Saint-Petersburg: Nauka, 2001, 231 p.
9. Tsinkernagel' R. Osnovy immunologii [Basics of immunology]. Moscow: Mir, 2008, 136 p.
10. Rot A. Eur. J. Immunol. 1993, vol. 23 (1), pp. 303–306.
11. Gilhar A., Ullmann Y., Kerner H., Assy B., Shalaginov R., Serafimovich S., Kalish R. S. J. Invest. Dermatol. 2002, vol. 119 (2), pp. 384–391.
12. Tobin A. M., Lynch L., Kirby B., O’Farrelly C. J. Innate Immun. 2011, vol. 3 (4), pp. 403–410. DOI 10.1159/000328011
13. Cameron A. L., Kirby B., Griffiths C. E. Br. J. Dermatol. 2003, vol. 149, pp. 160–164.
14. Privratsky J. R., Paddock C. M., Florey O., Newman D. K., Muller W. A., Newman P. J. J. Cell Sci. 2011, vol. 124 (pt. 9), pp. 1477–1485.
15. Galkina T. N., Kalmin O. V. Izvestiya vysshikh uchebnykh zavedeniy. Povolzhskiy region. Meditsinskie nauki [University proceedings. Volga region. Medical sciences]. 2017, no. 2 (42), pp. 31–41.
16. Khit B. Kh., Karter Dzh. E. L. Voprosy antropologii [Anthropology issues]. 1969, iss. 33, 19 p.


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